Primary hyperparathyroidism (PHPT) is an overactive thyroid gland and occurs primarily in middle-aged to old dogs. It represents a disturbance of the calcium metabolism, which brings with it secondary diseases.
In principle, any breed can be affected by PHPT, but it is frequently observed in the Wolfspitz.
Different from, for example, Dilution / CDA it does not require two carriers in the parent animals to pass on the changed allele. PHPT is inherited dominantly in the Wolfspitz.
A comprehensive report by Jane Saunders (2008) on PHPT in the Wolfspitz and the inheritance of the disease:
Symptoms of primary hyperparathyroidism
In addition to changes in the parathyroid glands, a tumor (kidney carcinoma) is often responsible for triggering the disease.
This results in an increase in blood calcium levels and a decrease in blood phosphorus levels. The body withdraws more and more calcium from the bones in a gradual process, which gradually leads to bone loss and calcium deposits in the internal organs. It is not uncommon for PHPT to be recognized from the age of 7.
It is strongly recommended that dogs are genetically tested for PHPT carriers at an early age.
In the USA, Dr. Goldstein a test that detects the gene (or a direct neighbor) that is held responsible for the development of PHPT.
Unfortunately, this check is currently only possible by sending a sample to the USA.
Detection in the early stages can improve the quality of life and, above all, extend the lifespan of the dog with the right therapy.
Sources: